Botox Different Formulations

When we speak about Botox, physicians and readers think of the formulation made by Allergan which is FDA approved. Actually other formulations are known and this could be confusing to readers.

Botulinum neurotoxins are produced by various strains of Clostridium Botulinum, of which A and B have been developed for routine clinical use. These various types of toxins have different properties and are used in varying dosage strengths. Only two formulations of Botox have been studied and used for cosmetic and therapeutic indications. The type A is known as the BOTOX® Cosmetic commonly used. The type B is known as Myobloc and is less suitable for cosmetic purposes because of the discomfort of injection and its acidity. Myobloc has a shorter duration of activity and is no longer used by most clinicians.

Another formulation is Dysport which is used in the United Kingdom and is currently undergoing FDA approval. Dysport is more likely to diffuse beyond the targeted muscle which can cause unwanted sequelae, and also has a shorter duration of activity.

Statistics for 2006 (latest available as of May 2008) show that BOTOX® Cosmetic injections continues to be the single most common aesthetic procedure performed in the United States, with nearly 3.2 million BOTOX® Cosmetic procedures performed. It is well recognized as one of the safest procedures available, and has a high level of patient satisfaction.

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